Such Sweet Sorrow

I kind of figured sugar would sneak back. It always does! Just when you think it should be terminally ashamed of the stuff it’s done, it shows up as somebody else and fools everybody. I mean, forget trying to pretend that you don’t recognize it in a crowd, that you can’t see under its mask. Sugar is, well, sugar, eh? No matter how it tries to sweet-talk its way around you, it is what it does. Period.

But what is that? Apart from fuelling our atavistic requirements for easily assimilable energy, and therefore surviving early Darwinian whittling, I’ve often wondered if there’s more to sugar than meets the tongue. It has too large a presence in our world to be confined to pleasure alone. Almost every organism seems drawn to it. Should this be telling us something?

Every once in a while my overweening, but naïve hunches are rewarded with information that addresses much the same issues but in ways I hadn’t considered: http://www.bbc.com/future/story/20180328-how-sugar-could-help-heal-wounds?

Moses Murandu is a man who grew up in the rural Easter Highlands of Zimbabwe, and later moved to England to work in its National Health System. ‘A senior lecturer in adult nursing at the University of Wolverhampton, Murandu completed an initial pilot study focussed on sugar’s applications in wound healing and won an award from the Journal of Wound Care in March 2018 for his work. […] To treat a wound with sugar, all you do, Murandu says, is pour the sugar on the wound and apply a bandage on top. The granules soak up any moisture that allows bacteria to thrive. Without the bacteria, the wound heals more quickly.

‘In some parts of the world, this procedure could be key because people cannot afford antibiotics. But there is interest in the UK, too, since once a wound is infected, it sometimes won’t respond to antibiotics. […] And a growing collection of case studies from around the world has supported Murandu’s findings, including examples of successful sugar treatments on wounds containing bacteria resistant to antibiotics.’

Well, it’s safe to say that I don’t know how much sugars will contribute to our health and well-being, but they do serve as a reminder that western science is not the sole guardian of knowledge. Or wisdom. Answers are not rare -they are lying around everywhere just waiting for the right questions to discover them. The right curiosity. And we run a risk dismissing traditional enlightenment -folk wisdom- out of hand.

The problem, as I see it, is one of attribution. The credibility we assign each source should be determined by the results of testing its hypothesis, finding the appropriate question to interrogate whatever is proposed as an answer. Finding the key that fits the lock… And the thesis investigated does not have to be of mind-bending importance; science is not the exclusive purview of people in white coats. Nor those of a certain age…

I recently happened upon a Tim Horton’s café in close approximation to a message from my stomach that it needed both a coffee and a bagel. Not being in the mood to argue, I decided to accede, although my loyalties normally lie with Starbucks. I had been wrestling with the question of habit on my walk –my strange unwillingness to explore new ground, consider new sources. Tim’s could be the answer waiting for the question.

Science, if it be considered from the inductive perspective, I reasoned, required the inference of laws from particular instances -answers from the right questions. In other words, Propose, Test, and then validate or refute. It isn’t enough to simply assume…

I had chosen a busy time unfortunately, and I was lucky to find a single table in a corner by the window. It was squeezed between a group of elderly women crowded around a larger table busy consuming their donuts and politely slurping their coffees, and a small table like mine occupied by a harried looking mother trying to bottle-feed a squirming, unhappy baby in her arms and a young boy busily kicking the legs of his chair.

The elders were surprisingly quiet, but not the little boy, so my ears naturally focussed on him.

“Why can’t we go, Mommy?” he kept asking.

I could tell his mother had almost reached the end of her tether, and she stared at him crossly, determined not to interrupt the feeding. “Because I’m still feeding Janny, Tim,” she replied, tensely. “She’s really hungry.”

The boy tilted his head curiously. “She’s squiggling around; she’s not even sucking…”

At that point the baby began to cry even louder-scream, actually- so the mother put the bottle on the table and positioned the baby on her shoulder to burp it.

But Tim still looked puzzled. “But she doesn’t like the bottle, Mommy,” he said, as if his mother should have noticed by now.

His mother shrugged, almost in tears. “I know, Timmy, but you were hungry too, remember? That’s why we came in here instead of going back to the car.”

Tim sat back in his chair for a moment to process the problem. “Well, why don’t you let Janny suck your breasts?” he said, in the rather loud voice of a four year old.

I could see his mother blush as soon as he said it, but Timmy had merely proposed a tentative hypothesis that could easily by tested to see if he had asked the right question, and his face was as innocent as a new nappy.

His mother leaned over the table with Janny so she could show Tim that they could talk quietly about it. “I would if we were sitting in the car…” she said, but he continued to stare at her, still puzzled. “And the car is still a long way away, Timmy.”

Tim leaned over the table like his mother. “Why can’t you breast her here?” he asked innocently.

She smiled and glanced around the room, embarrassed. “Some people don’t like to see mothers breast feed their babies in public.” She tried to whisper but Janny was really screaming now. She glanced at the washroom, no doubt wondering if she could feed her baby in there, but it must have been a small room, because there was already a line of needy hopefuls that had formed at the door

Tim smiled as if he knew how to solve the problem with his initial hypothesis, and he leaned towards me on his chair. “Hey mister,” he said in his best, grown-up voice, “Do you mind if Mommy breasts Janny in here?”

His mother was now beet red, and she glared at her little son and then attempted to smile at me. “I… I’m sorry…I…” But she was too embarrassed to continue.

“I don’t mind at all,” I said, trying to reassure her with a reciprocal smile. “You can use my jacket to cover yourself, if that would help…” I said, beginning to take off my jacket.

One of the elderly women at the next table leaned over and gave a thumbs-up to the frazzled mother. “We’ve all been there, dear,” she said and winked before she turned back to inspect her plate for donut remnants.

I handed the mother my jacket and the baby settled into the welcoming breast somewhere underneath. Propose, test, validate…

I added some extra sugar to my coffee, and settled back in my chair to celebrate the triumph of citizen science that even a child could perform. It’s just a matter of finding the right question, after all…

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Sweet Flowers are Slow

 

 

It never ceases to amaze me what unfettered minds can discover. Sometimes I wonder how they do it. How they set out 180 degrees from the target and still end up hitting it. Of course, the world is full of answers scattered like flowers in a field, in plain sight for anybody who has learned to see them. It’s not the answers that are hidden, just the appropriate questions. But maybe that’s the point –questions are often like detours pointing away from where you think you want to go, and yet arrive you do, having learned unexpected things along the way –Frost’s Road not Taken.

Socrates, although he initially disavowed the Delphic Oracle’s apocryphal pronouncement that he was the wisest man in Athens, knew that Truth, like Wisdom, was slippery. He realized he didn’t possess all the truth and so he asked many questions, whereas others -those who never thought to investigate- were complacent about their knowledge, unpuzzled by what they experienced, content with their grasp, however tenuous.

Maybe that’s just the way we’ve been taught to interrogate reality, though: if A equals C, and B also equals C, then we need look no further –A, B and C are equivalent, or at least interchangeable and otherwise individually uninteresting. Perhaps it takes a Socrates to ask why that is –or at least why we are satisfied with our assessment.

An article in the BBC News about an unusual approach to decreasing the spread of malaria brought this to mind: http://www.bbc.com/news/health-40495958  While researchers are trying desperately to engineer a vaccine, there have been many interesting attempts to ameliorate the prevalence of the disease. Some are relatively high tech –like genetically altering mosquitoes to produce genes to prevent the development of the malarial parasite within themselves and therefore stop its transmission to people when they bite; some are more humble methods, more attainable in the short term -such as pyrethroid-treated mosquito netting around beds. I suppose the boundaries between discovery and invention are fluid, but even so, either of them can lead to uncharted territories. New possibilities.

Still, until we do have an effective and safe vaccine, we need to use as many other methods to decrease the ravages of the female Anopheles mosquito as possible –however indirectly they may achieve this. Sometimes you just have to try stuff. Sometimes, you have to think inside the garden.

‘Gardening could be a powerful weapon against malaria, culling mosquito populations by cutting off their food supply, say researchers.’ The idea is to starve the mosquitoes before they get a chance to pass on the malarial parasite. A pilot project in Mali, West Africa, found that ‘Removing flowers from a common shrub appeared to kill off lots of the older, adult, female, biting insects that transmit malaria. Without enough nectar the “granny” mosquitoes starve, experts believe.

‘These Anopheles mosquitoes carry the malaria parasite in their salivary glands and pass it on to people when they bite and draw blood. The infected person can then infect other younger, biting, female mosquitoes – which are looking for a rich blood meal as they become fertile and make eggs – because their blood now contains the parasite. It takes about 10 days for a newly infected young female mosquito to become contagious to humans. By the time she can transmit malaria, she’s pretty old. Although she will feed on blood, she also relies on flower nectar for energy to stay alive.’

So, ‘Experts in Mali, along with researchers from the Hebrew University of Hadassah Medical School, Israel, and the University of Miami in the US, set up a horticultural experiment to see if removing the flowers from this plant might help kill off local mosquitoes. […]Villages where they removed the flowers saw mosquito numbers collected in the traps fall – the total number of mosquitoes across these villages decreased by nearly 60% after removal of the flowers.’

Admittedly, as the researchers concede, although it was an appropriate technique in a place like Mali, ‘it might not work so well in lush tropical regions where nectar-rich plants are in abundance.’

I suppose one of the reasons why this approach intrigued me so much, was that it seemed like a rather simple –albeit laborious- technique for mosquito control. Much like removing standing water that has collected in puddles or old tires where the mosquitoes can lay their eggs, it could be a community-led project that requires no additional external resources. But even more than that, as Professor Jo Lines, from the London School of Hygiene and Tropical Medicine, has observed, ‘”It appears to show that by changing the landscape, not using insecticides or drugs, we can make a difference.”’

What a thought –changing, not destroying something to achieve an aim. Being clever and asking the right questions about what was already in front of the eyes of anyone inquisitive enough to actually notice. Curious enough to ask ‘what if…?’

So, back to Socrates who, in the end, conceded that perhaps the Delphic Oracle had been right all along about him being the wisest man in Athens. He was still searching for knowledge, still questioning the completeness of what others had already decided was necessary for them to understand. He was still unprepared to pretend that he knew something he didn’t. To the end, he refused to accept that there weren’t always more questions to ask.

After all, it’s not what you look at that matters, it’s what you see; it’s not what you hear, so much as what you understand… The rest, as Hamlet said, is silence.

Hide and Seek

I guess the hunt is never over. Just when you think you’re winning, a sleeper cell surfaces, one you hadn’t even suspected, and closets itself somewhere you’d never think to look –an endless game of hide and seek. A Samsara of possibilities.

An yet, what would be the thrill of exploration if you knew all of the findings beforehand? We all need quests -adventures that uncover the hitherto unexpected, don’t you think? It’s what gets us out of bed in the morning. Me, anyway.

Questions and answers, for example… Let me play the devil’s advocate for a moment. We tend to assume that answers are the result of questions –we ask a question and then search for a correct -or at least appropriate– answer. But are we actually falling into a post hoc fallacy? ‘Post hoc, ergo propter hoc’ –because something occurred right after, or seems to be a response, we assume the initial thing caused the second. That’s just one way to look at it, of course. What if we assume there are answers lying around everywhere, and that the game is to find the appropriate question –the one that fits? A kind of ante hoc approach, I suppose, in which the answers come first.

Okay, try this. Answer: There are significant numbers of bacteria living under, and protected by, the fingernails. Question: Why doesn’t persistent scrubbing eliminate bacteria on the hands? I know this approach is merely a capricious inversion, but sometimes transpositions help us gain an interesting, if not useful, perspective. An article from BBC brought it to mind: http://www.bbc.com/future/story/20160622-what-lives-under-your-fingernails

I’m a surgeon, and early in my career it occurred to me that the water I was using at the scrub sink before an operation was itself not sterile. After a fastidious and lengthy hand and arm scrub with whatever cleansing soap was in vogue, I would then rinse off the soap with what amounted to tap water… And then, yes, I would observe ‘operating room technique’ and don sterile gloves for the procedure, but, apart from perhaps reducing the amount of whatever had been on my hands, what had all that scrubbing accomplished? Was it just a theoretical conjecture that it actually made a difference? A sop to sterile tradition? And if I were required to wear sterile gloves anyway why not just, I don’t know, use the same soap I used in the shower? It would certainly be cheaper. Questions! Questions swirling around hunting desperately for answers…

Had we posed the answer first, though… (Can you pose an answer?) Maybe the answer: ‘there are significant numbers of bacteria in the subungual compartment’ is a perfect fit for the question: why ‘is this hand region […] relatively inaccessible to antimicrobial agents during normal hand-washing procedures’?

Think about it for moment. Isn’t this the classic conundrum of basic science –science that is done for its own sake, science that has no existing practical applications? It consists of a whole platoon of answers to questions that have not yet been framed –or at least questions that were not anticipated at the time, or maybe just not the questions that were asked. A classic example of an answer (observation) looking for the right question was that of the findings of Penzias and Wilson –two physicists working on a new type of antenna at Bell Labs in New Jersey. In the early 1960ies they found a source of noise (the answer) in the atmosphere that they couldn’t explain. Finally, after eliminating other questions, they realized it was the cosmic microwave background (CMB) left over from the Big Bang. They received the 1978 Nobel Prize in physics for finding the proper question: ‘Is there any evidence of the Big Bang still around?’

And how about another answer: DNA is a large double helical molecule containing patterns of paired nucleotides and is found in cell nuclei for some reason. Question: why is it there? Or even: Could it be related to reproduction? Or heredity…?

Okay, I know this is a bit of a cart-before-the-horse stretch, but I think it does make us less complacent and maybe more appreciative of raw data. Details. Complexity. I’m not suggesting that Inductive logic is somehow flawed –it’s one of the fundamental tenets of the Scientific Method which posits using observation (answers) to derive general principles (more answers).

It’s not that confusing, really –it’s actually how things work in Science. The questions often arise because of the observations –after them, in other words- and so require experiments (questions) to see if the observations were indeed the answers…

So, isn’t the world a wonderful place? I ask that question -just one of many- after observing all the answers lying around unquestioned –unbothered, really- on the grass and among the flowers growing outside my window, all the unchallenged clouds in the sky above, and all the sunlight glinting off my polished floor.

I wonder, sometimes, whether the King James translation of the apostle Paul’s letter to the Corinthians was unwittingly prescient: ‘For now we see through a glass, darkly.’ And only when we recognize the importance of the observation, are we encouraged to ask why is that?